CLINICAL AND PHYSIOLOGICAL USAGE OF REABOX™
IN MEDICAL PRACTICE.

by
S. Belkin, MSEE
Z. Kravchenko, Ph.D., MD
EUROSCIENCE, San Diego, California · USA

The possibility of using carbon dioxide in therapeutic practice has attracted researchers' attention for some time. According to Monse's description (1909), scientists used carbon dioxide at health resorts in England, Germany, France, Czechoslovakia, Russia and other countries. Their patients sometimes were treated with carbon dioxide baths; in other cases natural post volcanic (mofet) gases were used. These contained approximately 98% carbon dioxide when its concentration in the air is 1.5 - 2.0. Design of the apparatus and methods of treatment had not been fully developed. The recommended apparatus keeps a proper concentration of carbon dioxide, temperature and humidity of gas mixture. Most importantly, it prevents the inhalation of the gas which in some certain concentrations can be toxic. A high relative humidity is essential in order to realize the therapeutic effects of carbon dioxide. Under these conditions one can observe the resorption not of free bubbling gas, but of carbonic acid absolutely dissolved and not yet discharged from the solution. Therefore, the term "dry" as it is used is conventional in the definition of the carbonic treatment.

Many years of research work by the specialists of Euroscience Company created the automatic installation REABOX™ for the purpose of "dry" carbonic treatment, by which many widespread diseases can be treated. What characteristics of carbonic gas are used in practice? It is well known that carbonic acid penetration through skin into the human organism decreases the sensitivity of cold receptors, improving the process of warmth creation and preventing the diminution of the body's temperature. The patient feels a pleasant warmth at the end of each treatment. This is caused by the considerable dilatation of the skin vessels by the action of carbonic acid on the walls of arteries and capillaries. The dilatation of the network of skin vessels accelerates the blood's current, lowers it viscosity and eliminates the stagnant conditions in skin vessels. Carbon dioxide dilatation the vessels promotes an increase in the number of functioning capillaries and arteria-vein shunts, thus improving collateral blood circulation.

Carbon dioxide as the main final product of metabolism acts as the chief factor in the regulation of gas exchange, and particularly in respiration. In 1904 Bor showed that the redundancy of carbonic acid in blood and tissues relieves the dissociation of oxyhemoglobin. For this reason with the same partial pressure of oxygen, blood which is rich in carbonic acid connects less oxygen than blood with less carbonic acid. This phenomenon is called "Bor's Effect". The curve of dissociation of oxyhemoglobin moves to the right when there is a high concentration of carbonic acid relative to oxygen, and as a result the affinity of hemoglobin decreases. This leads to the simplest return of oxygen by the oxyhemoglobin and increases the availability of oxygen to the tissues. In our research the results in determination of the tension of oxygen in arteria capillaries , volume speed of mussels capillary blood flow, having "dry" carbonic acid procedures at the phase of rehabilitation by patients with previously heart attacks. It is according to "Bor's Effect".

The carbonic acid also plays the main physiological role in the changing of hemodynamics. I.M.Sribner points out that transition of carbonic acid into blood current leads to increasing inflow of the veins, the minute and systole capacity is raised and that's why the unloading of the great circle of blood circulation and decreasing of blood pressure. It's most favorable for the patients with heart diseases in the cases of homeostasis (stagnation) in the great circle blood circulation. Besides this thanks to the diminution of vessels tonus and also decreasing of peripheral resistance, the increase of systole occurs, and creates the most favorable conditions for the heart - acceleration of blood current. Some researchers also show the role of carbonic acid as coronary vasodilator. It was confirmed by coronary angiography.

As a result of the influence of carbonic acid to the respiratory center leads to the deep and infrequent breathing, returning of blood to the heart, and improving ventilation and interchange of gases in lungs. The irritation of vasomotor center increases of vagus nerve tonus which is expressed in decreasing frequency of systole . Diastole pause is becoming longer, the heart works under favorable hemodynamic conditions because the increasing of coronary blood current appears exactly during diastole.

So the carbonic acid brought into organism is the unique regulator of the transportation of oxygen to tissues and metabolism in them, blood supply of organs and tissues. That's why the carbonic acid is used in medicine.

Until the present time the usage of the positive characteristics of carbonic acid in treatment of the patients with cardia-vascular and breathing diseases in water carbonic acid baths has been limited because of hydrostatic influence of water which is raising inter-chest pressure and is increasing vein blood return to the heart, and all these make additional difficulties to the heart acting and impedes the process of breathing. Carbonic gas, which is isolated from water during first five minutes, should be an extremely strong irritant especially for patients with stagnant heart insufficiency and with respiratory insufficiency.

Automatic apparatus REABOX™, if compared with water carbonic acid baths, is deprived of irritant hydrostatic effect and breathing of carbonic gas while using nature mofet procedures but keeping the effect of specific component - carbonic gas. It is used in the treatment of patients with disorders of compensation of cardiovascular and respiration systems and also in the treatment of other diseases.

The European countries using the accumulated information during past years about unique effect of carbonic gas revived the interest in the use of "dry" carbonic gas treatment in medical practice. This was not used before because of the absence of equipment, realizing the necessary technical characteristics and the absence of devising methodic of its use in the treatment of different diseases. Besides this the influence of this factor to cardia-respiration system in particular to the main links of oxygen transportation function of organism is not clear.

The effectiveness of studying factor in the treatment of patients with ischemia heart disease (after infarction cardiosclerosis) was established and this effectiveness was expressed in the decreasing of clinic-functional manifestations of insufficiency coronary and cardiac including the accompanying hypertension. The methodic of its use was worked out and the indications and contraindications were determined.

The information which was obtained in the process of using "dry" carbonic treatment at the second phase of period of rehabilitation of patients having heart attacks. It is recommended to use it on the 30th day from the beginning of disease (the period of convalescence). As a control, stream-air baths according to the same methodic but without supplying carbonic gas were used. It can be followed by the whole mechanism of creation of favorable effect of treatment of studied procedures. We can state the favorable influence of the oxygen transportation function of the organism forming the main mechanism of compensation of insufficiency of coronary and cardiac of patients have been having heart attacks.

In our opinion, the starting mechanism in realization of the medical effect of "dry" carbonic treatment of the patients having heart attacks at the recovering phase is the short time hypoxemia during the procedure as a result of increasing entering of carbonic acid to blood through skin, and appearing hyperventilation because of direct and reflex influence of carbonic acid. There were no worse effects in the conditions of patients as according to A. Wite's information the acceptation of oxygen by tissues is not decreased under conditions when carbonic acid is in abundant amount. The positive saturation of hemoglobin by oxygen is happening under the lower partial tension of oxygen. After the procedure the higher tension of oxygen of arterial- capillary blood was noticed, and it shows the improving of dissociation of oxyhemoglobin and the easiest returning back of oxygen to tissues (Bor's Effect). It leads to the increasing of oxygen capacity (the tension of oxygen arterial capillary blood giving the opportunity of constant through cutaneous measuring and is tightly connected with real PaO2 arteria blood. It was analyzed by us before, during , and 30-60 minutes after procedure).

So short hypoxemia during the procedure is the factor stimulating oxygen transportation function of blood circulation. The improvement of delivery and use of oxygen by tissues is the increasing of volume speed of muscles capillary tachogram (tissues periphery tachogram is the last link of oxygen transportation). It was determined by us according to clearance 133Xe and also the positive progress in ventilation and gas exchanging functions of the lungs according the results of respiratory function which is measuring by spirograph.

The combination of enumerating mechanisms of action equally with the exchanging of vegetative regulation of heart to the side of vagotony (diminution of the frequency of systole, the lengthening of diastole), positive dynamic electrocardiogram created the best conditions for the heart's acting which was expressed in the improvement of heart hemodynamic function both central (the increasing of beating and minute capacity of blood) and periphery hemodynamic (the lowering periphery resistance) with decreasing after loading to myocardium and the increasing of reserved opportunities of general circulation and myocardium. All these promoted earlier rehabilitation of broken at functions of cardia-vascular system, increasing the adaptation of general circulation and cardiac muscle to physical exercises (the doubling of multiplication on standard aid its increasing, decreasing, or disappearing of the signs of cardiac and coronary insufficiency. It's useful even to patients with stable stenocardia and hypertension which had contraindications to water baths therapy. The obtained information of clinic-functional researches prove the "dry" carbonic treatment as the method of pathogenetic therapy for the patients with heart attacks at the phase of rehabilitation. This is also useful for treatment at the stage of rehabilitation of such kind patients especially with the heavy period of recovering. The methods of its use are worked out, the indications and contraindications are determined.

At present time the specialists of EUROSCIENCE are continuing the starting research in the field of pulmonary and cardiology at the automatic apparatus for "dry" carbonic treatment REABOX™. Construction of this is according to all technical requirements, demands of this kind of treatment (the opportunity to keep given concentration of carbonic gas, temperature, and humidity of medical gas mixture, the exception of breathing gas). The high therapy effect was established for the patients with ischemic cardiac, including the patients with myocardium infarction at the phase and post recovering, hypertrophic myocardiopathy. There are no side effects. For different nosology groups of patients depending on the stage of course of pathology process and previous functional condition there were worked out optimal temperature's regime and doze of carbonic gas, leading to the maximum realization of positive effect of REABOX™. As we have already mentioned, the "dry" carbonic treatment is the best for using and further researching in order to introduce the apparatus REABOX™ in medical practice.

REABOX™ is trademark of EUROSCIENCE.



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